The Longterm Effect of Early Intensive Treatment of Seniors with Rheumatoid Arthritis: A Comparison of 2 Population-based Cohort Studies on Time to Joint Replacement Surgery

@article{Widdifield2016TheLE,
  title={The Longterm Effect of Early Intensive Treatment of Seniors with Rheumatoid Arthritis: A Comparison of 2 Population-based Cohort Studies on Time to Joint Replacement Surgery},
  author={Jessica Widdifield and Cristiano Soares de Moura and Yishu Wang and Michał Abrahamowicz and J. Michael Paterson and Anjie Huang and Marie-Eve Beauchamp and Gilles Boire and Paul R. Fortin and Louis Bessette and Claire Bombardier and John G. Hanly and Debbie Ehrmann Feldman and Sasha Bernatsky},
  journal={The Journal of Rheumatology},
  year={2016},
  volume={43},
  pages={861 - 868}
}
Objective. Disease-modifying antirheumatic drugs (DMARD) have the greatest effect when initiated early. We evaluated the influence of early exposure to DMARD on time to joint replacement surgery among patients with incident rheumatoid arthritis (RA). Method. Using a common protocol, we undertook 2 independent population-based cohort studies of patients with incident RA aged 66 years or older in Ontario (ON) and Quebec (QC) covering the period 2000–2013. We used Cox proportional hazards… 
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Treatment patterns in rheumatoid arthritis after discontinuation of methotrexate: data from the Ontario Best Practices Research Initiative (OBRI).
TLDR
Differences in subsequent treatment patterns exist between patients discontinuing MTX when used as monotherapy versus in combination with other csDMARDs where the former is more likely to use a subsequent monotherapy treatment.
Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004–2017)
TLDR
The number of TJRs decreased since the approval of biologics in Japan, and changes were observed in the characteristics of patients with rheumatoid arthritis undergoing TJR.
Rheumatoid Arthritis Therapy and Joint-replacement Surgery: Are We Making a Difference?
  • S. Goodman
  • Medicine
    The Journal of Rheumatology
  • 2016
TLDR
2 cohorts of incident RA patients over 66 years of age are described, the relationship between the use of methotrexate (MTX) and other disease-modifying antirheumatic drug (DMARD) therapy and the rate of arthroplasty is investigated, and the outcome of interest is described.
Delayed anti-TNF therapy increases the risk of total knee replacement in patients with severe rheumatoid arthritis
TLDR
Delayed initiation of anti-TNF therapy in the treatment of severe RA was associated with an increased risk of total knee replacement (TKR) surgery and adding methotrexate treatment decreased the risk of future TKR.
Management of rheumatoid arthritis: 2019 updated consensus recommendations from the Hong Kong Society of Rheumatology
TLDR
A treat-to-target approach is suggested to guide optimal sequencing of DMARDs in RA patients to achieve tight disease control and newly availableDMARDs are incorporated in the treatment algorithm, resulting in a greater range of second-line treatment options.
Predictors for orthopaedic surgery in patients with rheumatoid arthritis: results from a retrospective cohort study of 1010 patients diagnosed from 1972 to 2009 and followed up until 2015
TLDR
Patients with a diagnosis in the early years had a greatly increased risk of having orthopaedic surgery performed, probably due to the year of diagnosis being a proxy for the type and intensity of medical treatment.
Ultrasound detects synovitis in replaced and other surgically operated joints in rheumatoid arthritis patients
TLDR
In RA, joint replacement does not eliminate or prevent ultrasound measured synovitis, where all replaced joints have some evidence of US synovita, and US can also act as a potential marker of response to therapy in replaced joints.
Joint Surgery in Tunisian Rheumatoid Arthritis Patients: Prevalence and Risk Factors
TLDR
Predictive factors of surgery were age at disease onset, high ESR level and association of methotrexate with other csDMARDs.
Model-based methods for case definitions from administrative health data: application to rheumatoid arthritis
TLDR
A model-based method provides valuable empirical evidence to aid in selecting a definition(s) for ascertaining diagnosed disease cases from administrative health data for rheumatoid arthritis validation study.

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