• Corpus ID: 50952131

The Long-term Health Implications of Depo-Provera

@inproceedings{Spevack2013TheLH,
  title={The Long-term Health Implications of Depo-Provera},
  author={Edra Spevack},
  year={2013}
}
The reproductive health of adolescents and young adults is a major determinant of their future well-being. While Depo-Provera, or depot medroxyprogesterone acetate (DMPA), is highly effective at preventing pregnancy, mounting evidence suggests that its side effects may have a negative impact on long-term health. Together with mood changes, weight gain, menstrual irregularities, and delayed return to fertility, recent data indicate a correlation between DMPA use and an increased risk of fracture… 
imjournal.com
13 Citations
Background Citations
7
Results Citations
1

Tables from this paper

13 Citations

Partial Adrenal Suppression with Prolonged Use of Depo-Provera

A 49-year old patient presented with symptoms of adrenal suppression following an attempt to withdraw Depo-Provera or Depot Medroxyprogesterone Acetate (DMPA) injection, a known side effect of DMPA but occurring at a much lower dose than previously described.

Incidental Finding of Persistent Hydatidiform Mole in an Adolescent on Depo-Provera

This case is that of an adolescent female on Depo-Provera injectable contraceptive with increased vaginal bleeding, abdominal pain, nausea, and vomiting who was incidentally found to be pregnant and subsequently diagnosed with a molar pregnancy despite persistent denial of having initiated sexual intercourse.

TEH HIJAU MENURUNKAN KADAR KOLETEROL TOTAL PADA IBU AKSEPTOR KB DEPOMEDROXYPROGESTERONE ACETATE (DMPA)

Green tea was able to significantly reduced cholesterol levels in DMPA users, and this research needs to be refined to improve the accuracy of the cholesterol examination results using the POCT (Point of Care Testing) method or the spectrophotometer method.

RELATIONSHIP BETWEEN REPRODUCTIVE FACTORS AND DECREASED BONE DENSITY IN WOMEN

Given the key role of reproductive factors on bone density in women, it is necessary to apply optimal measures and contrivance in reproductive ages in terms of calcium intake and other nutrients and lifestyle adjustments in order to prevent some consequences of osteoporosis in nonreproductive ages by reducing the negative role of fertility factors.

Anthropometric Characteristics of Women on Hormonal Contraceptives in University of Port Harcourt Teaching Hospital (UPTH)

Except for skeletal muscle mass, women on hormonal contraceptives have higher but non-significant mean values for all anthropometric parameters compared to the control, which is relevant to gynecologists, obstetricians, family physicians, medical anthropologists and research scientists.

Oral contraceptives and intrauterine devices as risk factors for breast and cervical cancers: a systematic review

Overall, use of oral contraceptives upsurges risk of breast and cervical cancers especially when used for longer periods of time and further studies should therefore be done to understand the mechanisms of action of oral contraceptive and IUDs on the development of both cancers.

Papanicolaou smear interpretation with progestin-only hormonal birth control methods

POCs use is not associated with increased risk of abnormal cytologic findings and preinvasive disease of the cervix, and smoking including passive smoking has a positive association with abnormal Pap smears.

Potential Use of Antimicrobial Peptides as Vaginal Spermicides/Microbicides

Human cathelicidin LL-37 is the most promising spermicidal AMP to be further developed for vaginal use for the following reasons: it is a human AMP naturally produced in the vagina after intercourse that exerts microbicidal effects to numerous microbes including those that cause STI.

Role of transvaginal Doppler sonography in cases of irregular uterine bleeding with depot medroxyprogesterone acetate

Abnormal uterine bleeding with DMPA is associated with hemodynamic changes in transvaginal Doppler in form of increased blood flow in uterine and spiral arteries as indicated by significant decrease in RI and PI of both arteries.

Escherichia coli recombinant sperm immobilizing factor RecX as a potential vaginal contraceptive

Cloned, over-expressed an Escherichia coli gene encoding a sperm immobilizing factor (SIF) that inhibits sperm motility for the development of vaginal contraceptive from a biological source i.e. E. coli could be seen as potential target to be developed as potent and safe vaginal contraceptive in future.

References

SHOWING 1-10 OF 81 REFERENCES

Depot-medroxyprogesterone acetate injection (Depo-Provera): a highly effective contraceptive option with proven long-term safety.

Use of hormonal contraception in adolescents: skeletal health issues

Although more data on skeletal health outcomes following the use of oral and injectable contraceptives would be welcomed, theoretic concerns regarding the impact of depot medroxyprogesterone acetate and combination oral contraceptives on adolescent and young women should not restrict the initiation or continuation of these important contraceptive methods.

Effect of depot medroxyprogesterone acetate on bone density in a Scottish industrial city

  • P. McGoughA. Bigrigg
  • Medicine
    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2007
DMPA significantly decreases bone density in a group of long-term users with significant social deprivation, and this difference remained even when controlling for parity, smoking, family history of kyphosis or hip fracture, and body mass index.

Use of depot medroxyprogesterone acetate and fracture risk.

This population-based study suggests that use of DMPA is associated with a slightly increased risk of fractures.

Bone mineral density and depot medroxyprogesterone acetate.

Bone density recovery after depot medroxyprogesterone acetate injectable contraception use.

Effects of Depot medroxyprogesterone acetate on bone density and bone metabolism before and after peak bone mass: a case-control study.

DMPA use is associated with a bone density deficit at the spine and hip in women who started DMPA use before age 20 yr but not after age 34 yr when used before peak bone mass.

Low-dose oral contraceptives in adolescents: how low can you go?

Hormonal contraception and HIV: an unanswered question.

U.S. approves injectable drug as birth control.

On October 29 1992 the US Food and Drug Administration (USFDA) approved use of the contraceptive injectable Depo-Provera. This approval ends two decades of controversy over the potential carcinogenic…
...