The Long Noncoding RNA IFNG-AS1 Promotes T Helper Type 1 Cells Response in Patients with Hashimoto’s Thyroiditis

  title={The Long Noncoding RNA IFNG-AS1 Promotes T Helper Type 1 Cells Response in Patients with Hashimoto’s Thyroiditis},
  author={Hui-yong Peng and Yingzhao Liu and J. Tian and J. Ma and Xinyi Tang and Ke Rui and X. Tian and C. Mao and L. Lu and H. Xu and Pengcheng Jiang and S. Wang},
  journal={Scientific Reports},
  • Hui-yong Peng, Yingzhao Liu, +9 authors S. Wang
  • Published 2015
  • Biology, Medicine
  • Scientific Reports
  • The long noncoding (lnc) RNA-Ifng-AS1 plays an essential role in the transcription of the gene encoding IFN-γ by Th1 cells, and its human ortholog, IFNG-AS1, is expressed in human Th1 cells. However, IFNG-AS1 contributing to Th1 cells’ response in Hashimoto’s thyroiditis (HT) patients has not been reported. Twenty-eight HT patients and 20 healthy controls were enrolled in the study. The proportion of circulating Th1 cells and the level of T-bet, IFNG mRNA were increased in HT patients, the… CONTINUE READING
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