The Loci of Evolution: How Predictable is Genetic Evolution?

  title={The Loci of Evolution: How Predictable is Genetic Evolution?},
  author={David L Stern and Virginie Orgogozo},
  journal={Evolution; International Journal of Organic Evolution},
  pages={2155 - 2177}
Is genetic evolution predictable? Evolutionary developmental biologists have argued that, at least for morphological traits, the answer is a resounding yes. Most mutations causing morphological variation are expected to reside in the cis-regulatory, rather than the coding, regions of developmental genes. This "cis-regulatory hypothesis" has recently come under attack. In this review, we first describe and critique the arguments that have been proposed in support of the cis-regulatory hypothesis… CONTINUE READING
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