The Local Effects of Ovarian Diathermy in an Ovine Model of Polycystic Ovary Syndrome

  title={The Local Effects of Ovarian Diathermy in an Ovine Model of Polycystic Ovary Syndrome},
  author={F. Connolly and M. Rae and M. Butler and A. Klibanov and V. Sboros and A. Mcneilly and W. C. Duncan},
  journal={PLoS ONE},
  • F. Connolly, M. Rae, +4 authors W. C. Duncan
  • Published 2014
  • Medicine
  • PLoS ONE
  • In order to develop a medical alternative to surgical ovarian diathermy (OD) in polycystic ovary syndrome (PCOS) more mechanistic information is required about OD. We therefore studied the cellular, molecular and vascular effects of diathermy on the ovary using an established ovine model of PCOS. Pregnant sheep were treated twice weekly with testosterone propionate (100 mg) from day 30–100 gestation. Their female offspring (n = 12) were studied during their second breeding season when the PCOS… CONTINUE READING
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