The Local Effects of Ovarian Diathermy in an Ovine Model of Polycystic Ovary Syndrome

@article{Connolly2014TheLE,
  title={The Local Effects of Ovarian Diathermy in an Ovine Model of Polycystic Ovary Syndrome},
  author={Fiona Connolly and Michael T. Rae and Mairead B. Butler and Alexander L. Klibanov and Vassilis Sboros and Alan S. Mcneilly and William Colin Duncan},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
In order to develop a medical alternative to surgical ovarian diathermy (OD) in polycystic ovary syndrome (PCOS) more mechanistic information is required about OD. We therefore studied the cellular, molecular and vascular effects of diathermy on the ovary using an established ovine model of PCOS. Pregnant sheep were treated twice weekly with testosterone propionate (100 mg) from day 30–100 gestation. Their female offspring (n = 12) were studied during their second breeding season when the PCOS… 

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References

SHOWING 1-10 OF 77 REFERENCES
Enhanced thecal androgen production is prenatally programmed in an ovine model of polycystic ovary syndrome.
TLDR
In vitro the thecal cells of follicles secreted more LH-stimulated androstenedione after prenatal androgenization, suggesting a thecal defect induced during fetal life, the first evidence of increased thecal androgenic capacity in the absence of a PCOS phenotype.
The impact of insulin resistance on the outcome of laparoscopic ovarian diathermy in women with polycystic ovarian syndrome
TLDR
Insulin resistance appears to have an adverse effect on the outcome of LOD and seems to be a useful prognostic factor.
Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS): relationship to the ovulatory response.
TLDR
Irrespective of its systemic effects, the efficacy of metformin in the induction of ovulation is probably due to a direct action on the ovary, and the ovulatory response to the drug seems to be related to local sensitivity or resistance to theDrug.
Sheep models of polycystic ovary syndrome phenotype
Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries.
TLDR
This is the first report of a difference in thecal androgen production between normal and polycystic ovaries and supports the hypothesis that there is a primary abnormality in the regulation of androgens production in PCOS.
Laparoscopic ovarian treatment in infertile patients with polycystic ovarian syndrome (PCOS): endocrine changes and clinical outcome.
TLDR
Ovarian electrocautery is an effective procedure to improve the intraovarian mechanism of selecting a dominant follicle for patients with PCOS in whom initial medical management fails, and it appears to be one of the possible treatments for this disease.
Ovarian electrocautery in the treatment of women with polycystii ovary syndrome (PCOS): Factors affecting the results
TLDR
During ihe years 1979-91 252 women with polycystic ovarian syndrome (PCOS) have been treated with ovarian electrocautery through the laparoscope in Aker University Hospital, with the pregnancy rates of slim and overweight women with PCOS being 92% and 95%, respectively.
Ovarian electrocautery in the treatment of women with polycystii ovary syndrome (PCOS): Factors affecting the results
  • H. Gjønnaess
  • Medicine
    Acta obstetricia et gynecologica Scandinavica
  • 1994
TLDR
During ihe years 1979‐91 252 women with polycystic ovarian syndrome (PCOS) have been treated with ovarian electrocautery through the laparoscope in Aker University Hospital, with ovulation obtained in 92% and pregnancy obtained in 84% of the women as the sole cause of their infertility.
Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone.
TLDR
It is suggested that prenatal T treatment leads to offspring with reduced birth weight and impaired insulin sensitivity in early postnatal life.
...
1
2
3
4
5
...