The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation

@article{Fujii2004TheLO,
  title={The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation},
  author={Shin-ichiro Fujii and Kang Liu and Caroline Smith and Anthony J. Bonito and Ralph Marvin Steinman},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={199},
  pages={1607 - 1618}
}
Dendritic cell (DC) maturation is an innate response that leads to adaptive immunity to coadministered proteins. To begin to identify underlying mechanisms in intact lymphoid tissues, we studied alpha-galactosylceramide. This glycolipid activates innate Valpha14(+) natural killer T cell (NKT) lymphocytes, which drive DC maturation and T cell responses to ovalbumin antigen. Hours after giving glycolipid i.v., tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma were released primarily by… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 262 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 59 references

Dynamic regulation of T cell tolerance induced by dendritic cells in vivo

  • D. Hawiger, R. F. Masilamani, E. Bettelli, V. K. Kuchroo, M. C. Nussenzweig
  • 2004
1 Excerpt

Similar Papers

Loading similar papers…