The Limits of Two-Year Bioassay Exposure Regimens for Identifying Chemical Carcinogens

@article{Huff2008TheLO,
  title={The Limits of Two-Year Bioassay Exposure Regimens for Identifying Chemical Carcinogens},
  author={J. Huff and M. Jacobson and D. Davis},
  journal={Environmental Health Perspectives},
  year={2008},
  volume={116},
  pages={1439 - 1442}
}
Background Chemical carcinogenesis bioassays in animals have long been recognized and accepted as valid predictors of potential cancer hazards to humans. Most rodent bioassays begin several weeks after birth and expose animals to chemicals or other substances, including workplace and environmental pollutants, for 2 years. New findings indicate the need to extend the timing and duration of exposures used in the rodent bioassay. Objectives In this Commentary, we propose that the sensitivity of… Expand
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