The Light Peak of the Electroretinogram Is Dependent on Voltage-gated Calcium Channels and Antagonized by Bestrophin (Best-1)

@article{Marmorstein2006TheLP,
  title={The Light Peak of the Electroretinogram Is Dependent on Voltage-gated Calcium Channels and Antagonized by Bestrophin (Best-1)},
  author={Lihua Y. Marmorstein and Jiang Wu and Precious J. McLaughlin and John Yocom and Mike O Karl and Rudgar Neussert and Soenke Wimmers and James Brett Stanton and Ronald G Gregg and Olaf Strauss and Neal S Peachey and Alan D. Marmorstein},
  journal={The Journal of General Physiology},
  year={2006},
  volume={127},
  pages={577 - 589}
}
Mutations in VMD2, encoding bestrophin (best-1), cause Best vitelliform macular dystrophy (BMD), adult-onset vitelliform macular dystrophy (AVMD), and autosomal dominant vitreoretinochoroidopathy (ADVIRC). BMD is distinguished from AVMD by a diminished electrooculogram light peak (LP) in the absence of changes in the flash electroretinogram. Although the LP is thought to be generated by best-1, we find enhanced LP luminance responsiveness with normal amplitude in Vmd2-/- mice and no differences… CONTINUE READING
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