The Ligand Binding Site of the Platelet Integrin Receptor GPIIb-IIIa Is Proximal to the Second Calcium Binding Domain of Its cx

Abstract

The extreme carboxyl-terminal amino acid sequence of the y chain of fibrinogen is involved in the binding of this adhesive protein to the platelet integrin glycoprotein (GP) IIb-IIIa, and synthetic peptides corresponding to this region inhibit fibrinogen as well as fibronectin and von Willebrand factor binding to platelets. A chemical cross-linking approach… (More)

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