The Life Story of Hydrogen Peroxide III: Chirality and Physical Effects at the Dawn of Life

@article{Ball2015TheLS,
  title={The Life Story of Hydrogen Peroxide III: Chirality and Physical Effects at the Dawn of Life},
  author={Rowena Ball and John Brindley},
  journal={Origins of Life and Evolution of Biospheres},
  year={2015},
  volume={46},
  pages={81-93}
}
  • R. Ball, J. Brindley
  • Published 1 March 2016
  • Biology, Chemistry
  • Origins of Life and Evolution of Biospheres
It is a remarkable observed fact that all life on Earth is homochiral, its biology using exclusively the D-enantiomer of ribose, the sugar moiety of the ribonucleic acids, and the L-enantiomers of the chiral amino acids. Motivated by concurrent work that elaborates further the role of hydrogen peroxide in providing an oscillatory drive for the RNA world (Ball & Brindley 2015a, J. R. Soc. Interface 12, 20150366, and Ball & Brindley 2015b, this journal, in press), we reappraise the structure and… 
The Power Without the Glory: Multiple Roles of Hydrogen Peroxide in Mediating the Origin of Life.
TLDR
The HP crucible hypothesis is radical, but based on well-known chemistry and physics, it is eminently testable in the laboratory, and many of the simulations provide recipes for such experiments.
The life story of hydrogen peroxide II: a periodic pH and thermochemical drive for the RNA world
TLDR
It is affirm that concern over the alleged toxicity of hydrogen peroxide to life is largely misplaced in the current context, and its occurrence in the solar system is surveyed to motivate its inclusion as a biosignature in the search for life on other worlds.
Thiosulfate-Hydrogen Peroxide Redox Oscillator as pH Driver for Ribozyme Activity in the RNA World
TLDR
Three important ways in which the dynamic hydrogen peroxide medium may have acted as an agent for development of the RNA world towards a cellular world are discussed: proton gradients, resolution of the ribozyme versus replication paradox, and vesicle formation.
Estudo da taxa de transição de conformações quirais do peróxido de hidrogênio isolado e na presença de gases nobres
In recent years, the study of molecules with chirality has been increasing. Hydrogen peroxide (H2O2) is the simplest molecule that presents this property. H2O2 has a great importance in several
A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging.
TLDR
It is shown how aging can result from the inherent chemical reactivity of many biomolecules, not just ROS, which imposes a fundamental constraint on biological evolution.
A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging.
TLDR
Here, it is shown how aging can result from the inherent chemical reactivity of many biomolecules, not just ROS, which imposes a fundamental constraint on biological evolution.
Reactive Oxygen Species: Radical Factors in the Evolution of Animal Life: A molecular timescale from Earth's earliest history to the rise of complex life.
TLDR
Although harnessing of chemical and thermo-dynamic properties of O2 for aerobic metabolism is generally considered to be an evolutionary milestone, the ability to use ROS for cell signaling and regulation may have been the first true breakthrough in development of complex life.
Tight electrostatic regulation of the OH production rate from the photolysis of hydrogen peroxide adsorbed on surfaces
TLDR
The results show that the photochemistry of H2O2 in heterogeneous environments is greatly modulated by the nature of the surface, and this finding opens interesting new perspectives for technological and biomedical applications, and possibly in various atmospheres.
Disentangling the molecular nature of the benchmark molecule H2O2 through many-body fragmentation dynamics
Universality in fragmentation has been the framework of scientific interest from a considerable period to disentangle the structure and dynamics of atoms and molecules. Studies in this direction
Theoretical Investigation on H2O2-Ng (He, Ne, Ar, Kr, Xe, and Rn) Complexes Suitable for Stereodynamics: Interactions and Thermal Chiral Rate Consequences
TLDR
The results show that the CRT is highly affected even at a small decrease in the height of trans-barrier; that the decrease of CRT shows an inverse correlation with respect to the average valence electron energy of the Ng and that Ne and He may be the noble gases more suitable for study the oriented collision dynamics of HP.
...
...

References

SHOWING 1-10 OF 53 REFERENCES
The life story of hydrogen peroxide II: a periodic pH and thermochemical drive for the RNA world
TLDR
It is affirm that concern over the alleged toxicity of hydrogen peroxide to life is largely misplaced in the current context, and its occurrence in the solar system is surveyed to motivate its inclusion as a biosignature in the search for life on other worlds.
Thiosulfate-Hydrogen Peroxide Redox Oscillator as pH Driver for Ribozyme Activity in the RNA World
TLDR
Three important ways in which the dynamic hydrogen peroxide medium may have acted as an agent for development of the RNA world towards a cellular world are discussed: proton gradients, resolution of the ribozyme versus replication paradox, and vesicle formation.
Chiral discrimination in hydrogen-bonded complexes of hydrogen peroxide with methyl hydroperoxide: Theoretical study
For the first time, the discrimination of different chiral forms of 1:1 complexes with hydrogen peroxide and methyl hydroperoxide have been investigated using density functional theory (DFT) and
Chiral discrimination in hydrogen-bonded complexes of 2-fluorooxirane with hydrogen peroxide
The paper reports on an ab initio investigation of an extensive series of propylene oxide (PO)···hydrogen peroxide (HOOH) complexes to investigate chiral discrimination. Second-order Møller–Plesset
Chiral discrimination in hydrogen‐bonded complexes of butan‐2‐ol (m‐form) and hydrogen peroxide
A theoretical study was reported on the chiral discrimination of different chiral formers of hydrogen-bonded complexes of butan-2-ol (m-form of “ga,” “ag,” and “gg”) with hydrogen peroxide. This
Emergence of homochirality in far-from-equilibrium systems: mechanisms and role in prebiotic chemistry.
TLDR
The APED model is presented as the most natural realization of such thermodynamic openness and non-equilibrium, of recycling and of network autocatalysis, each of these in prebiotic conditions and the place and role of such self-structured networks responsible for the presence of homochirality in the primitive Earth is detailed.
Influence of the 2'-hydroxyl group conformation on the stability of A-form helices in RNA.
Escalation of polymerization in a thermal gradient
TLDR
The results confirm that a thermal gradient can significantly enlarge the available sequence space for the emergence of catalytically activePolymerization and accumulation become mutually self-enhancing and result in a hyperexponential escalation of polymer length.
Oxidation of 2′-deoxyguanosine by H2O2–ascorbate: evidence against free OH˙ and thermodynamic support for two-electron reduction of H2O2
TLDR
High concentrations of the hydroxyl radical (OH˙) scavengers PBN, DMPO, pentoxifylline and imidazole had a very limited protective effect on 8-oxodG formation, which provides evidence against free OH˙ production as the major mechanism.
...
...