The Lewy body variant of Alzheimer’s disease: clinical, pathophysiological and conceptual issues

@article{Frstl1999TheLB,
  title={The Lewy body variant of Alzheimer’s disease: clinical, pathophysiological and conceptual issues},
  author={Hans F{\"o}rstl},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={1999},
  volume={249},
  pages={S64-S67}
}
In 1923, Friedrich H. Lewy described dementia with Lewy bodies in a large proportion of his patients with paralysis agitans which had co-incident plaques and neurofibrillary tangles. The potential contribution of Lewy bodies to a dementia syndrome with fluctuating course, visual hallucinations, Parkinsonian features and neuroleptic hypersensitivity was rediscovered many decades later. The comorbidity of Alzheimer’s and Parkinson’s disease is not uncommon as both diseases show an exponential… CONTINUE READING

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