The Lewy Body in Parkinson’s Disease and Related Neurodegenerative Disorders

@article{Wakabayashi2012TheLB,
  title={The Lewy Body in Parkinson’s Disease and Related Neurodegenerative Disorders},
  author={Koichi Wakabayashi and Kunikazu Tanji and Saori Odagiri and Yasuo Miki and Fumiaki Mori and Hitoshi Takahashi},
  journal={Molecular Neurobiology},
  year={2012},
  volume={47},
  pages={495-508}
}
The histopathological hallmark of Parkinson’s disease (PD) is the presence of fibrillar aggregates referred to as Lewy bodies (LBs), in which α-synuclein is a major constituent. Pale bodies, the precursors of LBs, may serve the material for that LBs continue to expand. LBs consist of a heterogeneous mixture of more than 90 molecules, including PD-linked gene products (α-synuclein, DJ-1, LRRK2, parkin, and PINK-1), mitochondria-related proteins, and molecules implicated in the ubiquitin… CONTINUE READING
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