The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum.

@article{Westwood2009TheLC,
  title={The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum.},
  author={Jennifer A Westwood and William K. Murray and Melanie K. Trivett and Nicole M. Haynes and Benjamin E. Solomon and Linda Rose Mileshkin and David C Ball and Michael Michael and Angela C Burman and Preethi Mayura-Guru and Joseph A. Trapani and Stefan Peinert and Dirk H{\"o}nemann and H. Miles Prince and Andrew Mark Scott and Mark J Smyth and Phillip K Darcy and Michael Kershaw},
  journal={Journal of immunotherapy},
  year={2009},
  volume={32 3},
  pages={292-301}
}
In this study we aimed to determine the suitability of the Lewis-Y carbohydrate antigen as a target for immunotherapy using genetically redirected T cells. Using the 3S193 monoclonal antibody and immunohistochemistry, Lewis-Y was found to be expressed on a range of tumors including 42% squamous cell lung carcinoma, 80% lung adenocarcinoma, 25% ovarian carcinoma, and 25% colorectal adenocarcinoma. Expression levels varied from low to intense on between 1% and 90% of tumor cells. Lewis- was also… CONTINUE READING
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