The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis

@inproceedings{Mahmoudi2010TheLM,
  title={The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis},
  author={Tokameh Mahmoudi and Sylvia F. Boj and Pantelis Hatzis and Vivian S W Li and Nadia Taouatas and Robert G. J. Vries and H Eric Teunissen and Harry Begthel and Jeroen Korving and Shabaz Mohammed and Albert J. R. Heck and Hans Clevers},
  booktitle={PLoS biology},
  year={2010}
}
Wnt signaling maintains the undifferentiated state of intestinal crypt progenitor cells by inducing the formation of nuclear TCF4/β-catenin complexes. In colorectal cancer, activating mutations in Wnt pathway components cause inappropriate activation of TCF4/β-catenin-driven transcription. Despite the passage of a decade after the discovery of TCF4 and β-catenin as the molecular effectors of the Wnt signal, few transcriptional activators essential and unique to the regulation of this… CONTINUE READING

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Linking H 3 K 79 trimethylation to Wnt signaling through a novel Dot 1 - containing complex

RK Slany
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