The Lengthening of a Giant Protein: When, How, and Why?

  title={The Lengthening of a Giant Protein: When, How, and Why?},
  author={Olivier Meiniel and Robert Meiniel and Fabrice Lalloue and Robert Didier and Marie-Odile Jauberteau and Annie Meiniel and Daniel Petit},
  journal={Journal of Molecular Evolution},
Subcommissural organ (SCO)-spondin is a giant glycoprotein of more than 5000 amino acids found in Vertebrata, expressed in the central nervous system and constitutive of Reissner’s fiber. For the first time, in situ hybridization performed on zebrafish (Danio rerio) embryos shows that the gene encoding this protein is expressed transitionally in the floor plate, the ventral midline of the neural tube, and later in the diencephalic third ventricle roof, the SCO. The modular organization of the… CONTINUE READING
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