The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose

@article{Frey1996TheLP,
  title={The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose},
  author={P. Frey},
  journal={The FASEB Journal},
  year={1996},
  volume={10},
  pages={461 - 470}
}
  • P. Frey
  • Published 1996
  • Chemistry, Medicine
  • The FASEB Journal
ABSTRACT: The biological interconversion of galactose and glucose takes place only by way of the Leloir pathway and requires the three enzymes galactoki‐ nase, galactose‐1‐P uridylyltransferase, and UDP‐ galactose 4‐epimerase. The only biological importance of these enzymes appears to be to provide for the interconversion of galactosyl and glucosyl groups. Galactose mutarotase also participates by producing the galactokinase substrate α‐D‐galactose from its β‐anomer. The galacto/gluco… Expand
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