The Leishmania dono 6 ani LD 1 locus gene ORFG encodes a biopterin transporter ( BT 1 )

@inproceedings{Lemley1999TheLD,
  title={The Leishmania dono 6 ani LD 1 locus gene ORFG encodes a biopterin transporter ( BT 1 )},
  author={Craig Lemley and Shaofeng Yan and Vandana S. Dole and Rentala Madhubala and Mark L. Cunningham and Stephen M Beverley and Peter J. Myler and Kenneth D. Stuart},
  year={1999}
}
We have previously described two genes, ORFF and ORFG, from the LD1 locus near one telomere of chromosome 35, which are frequently amplified in Leishmania isolates. In Leishmania dono6ani LSB-51.1, gene conversion of the rRNA gene locus on chromosome 27 with these two genes resulted in their over-expression, because of their transcription by the RNA polymerase I-mediated rRNA promoter. The predicted ORFG protein has substantial sequence homology to the ESAG10 gene product from the Trypanosoma… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Similar Papers

Loading similar papers…