The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase.

@article{Lgar2001TheLA,
  title={The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase.},
  author={Danielle L{\'e}gar{\'e} and D. D. Richard and R. R. Mukhopadhyay and York Stierhof and Barry P. Rosen and Anass Haimeur and Barbara Papadopoulou and Marc A. Ouellette},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 28},
  pages={26301-7}
}
The Leishmania ATP-binding cassette (ABC) transporter PGPA is involved in metal resistance (arsenicals and antimony), although the exact mechanism by which PGPA confers resistance to antimony, the first line drug against Leishmania, is unknown. The results of co-transfection experiments, transport assays, and the use of inhibitors suggest that PGPA recognizes metals conjugated to glutathione or trypanothione, a glutathione-spermidine conjugate present in Leishmania. The HA epitope tag of the… CONTINUE READING
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