The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor

@article{Murata2006TheLP,
  title={The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor},
  author={Takahiro Murata and A Delprato and Alyssa Ingmundson and Derek Toomre and David G. Lambright and Craig R Roy},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={971-977}
}
The intracellular pathogen Legionella pneumophila avoids fusion with lysosomes and subverts membrane transport from the endoplasmic reticulum to create an organelle that supports bacterial replication. Transport of endoplasmic reticulum-derived vesicles to the Legionella-containing vacuole (LCV) requires bacterial proteins that are translocated into host cells by a type IV secretion apparatus called Dot/Icm. Recent observations have revealed recruitment of the host GTPase Rab1 to the LCV by a… CONTINUE READING
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