The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.

@article{Conover2003TheLP,
  title={The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.},
  author={Gloria M. Conover and Isabelle Derr{\'e} and Joseph P. Vogel and Ralph R Isberg},
  journal={Molecular microbiology},
  year={2003},
  volume={48 2},
  pages={305-21}
}
Legionella pneumophila establishes a replication vacuole within phagocytes that requires the bacterial Dot/Icm apparatus for its formation. This apparatus is predicted to translocate effectors into host cells. We hypothesized that some translocated proteins also function to maintain the integrity of the Dot/Icm translocator. Mutations that destroy this function are predicted to result in a Dot/Icm complex that poisons the bacterium, resulting in reduced viability. To identify such mutants… CONTINUE READING

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