The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling.

@article{Hsu2014TheLE,
  title={The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling.},
  author={FoSheng Hsu and Xi Luo and Jiazhang Qiu and Yan-Bin Teng and Jianping Jin and Marcus Bustamante Smolka and Zhao-Qing Luo and Yuxin Mao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 29},
  pages={10538-43}
}
The activity of proteins delivered into host cells by the Dot/Icm injection apparatus allows Legionella pneumophila to establish a niche called the Legionella-containing vacuole (LCV), which is permissive for intracellular bacterial propagation. Among these proteins, substrate of Icm/Dot transporter (SidC) anchors to the cytoplasmic surface of the LCV and is important for the recruitment of host endoplasmic reticulum (ER) proteins to this organelle. However, the biochemical function underlying… CONTINUE READING