The Latent Membrane Protein 1 (LMP1) Oncogene of Epstein-Barr Virus Can Simultaneously Induce and Inhibit Apoptosis in B Cells

@article{Pratt2012TheLM,
  title={The Latent Membrane Protein 1 (LMP1) Oncogene of Epstein-Barr Virus Can Simultaneously Induce and Inhibit Apoptosis in B Cells},
  author={Zachary L Pratt and J. Zhang and B. Sugden},
  journal={Journal of Virology},
  year={2012},
  volume={86},
  pages={4380 - 4393}
}
  • Zachary L Pratt, J. Zhang, B. Sugden
  • Published 2012
  • Biology, Medicine
  • Journal of Virology
  • ABSTRACT The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) regulates its own expression and the expression of human genes via its two functional moieties; the transmembrane domains of LMP1 are required to regulate its expression via the unfolded protein response (UPR) and autophagy in B cells, and the carboxy-terminal domain of LMP1 activates cellular signaling pathways that affect cellular proliferation and survival. An apparent anomaly in the complex regulation of the UPR and… CONTINUE READING
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