The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes.

@article{Markert2008TheLP,
  title={The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes.},
  author={Andreas Markert and Michael J. Grimm and Javier de La Puente Martinez and Julia Wiesner and Andreas Meyerhans and Oded Meyuhas and Albert Sickmann and Utz Fischer},
  journal={EMBO reports},
  year={2008},
  volume={9 6},
  pages={569-75}
}
The positive transcription elongation factor b (P-TEFb) is a heterodimeric complex composed of cyclin-dependent kinase 9 and its regulator cyclin T1/2. It stimulates transcription elongation by phosphorylation of serine 2 residues in the carboxy-terminal domain of polymerase II. 7SK RNA and HEXIM proteins can antagonize transcriptional stimulation by sequestering P-TEFb in a catalytically inactive ribonucleoprotein (RNP). Here, we show that the previously uncharacterized La-related protein 7… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme

  • C Jeronimo
  • Mol Cell
  • 2007

Similar Papers

Loading similar papers…