The La protein functions redundantly with tRNA modification enzymes to ensure tRNA structural stability.

@article{Copela2006TheLP,
  title={The La protein functions redundantly with tRNA modification enzymes to ensure tRNA structural stability.},
  author={Laura A Copela and Ghadiyaram Chakshusmathi and Rachael L Sherrer and Sandra L Wolin},
  journal={RNA},
  year={2006},
  volume={12 4},
  pages={644-54}
}
Although the La protein stabilizes nascent pre-tRNAs from nucleases, influences the pathway of pre-tRNA maturation, and assists correct folding of certain pre-tRNAs, it is dispensable for growth in both budding and fission yeast. Here we show that the Saccharomyces cerevisiae La shares functional redundancy with both tRNA modification enzymes and other proteins that contact tRNAs during their biogenesis. La is important for growth in the presence of mutations in either the arginyl tRNA… CONTINUE READING

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