The LPL gene in individuals with familial combined hyperlipidemia and decreased LPL activity.

@article{Nevin1994TheLG,
  title={The LPL gene in individuals with familial combined hyperlipidemia and decreased LPL activity.},
  author={D N Nevin and John D. Brunzell and Samir S. Deeb},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1994},
  volume={14 6},
  pages={
          869-73
        }
}
Familial combined hyperlipidemia (FCHL) is an oligogenic disorder, with family members having elevated apolipoprotein B-100 levels and either elevated plasma cholesterol or triglyceride levels or both. Obligate heterozygous parents of children with lipoprotein lipase (LPL) deficiency express a mild FCHL phenotype. Of patients with FCHL, 36% have diminished postheparin LPL activity and mass values that are comparable with those of obligate heterozygotes for LPL deficiency. It is hypothesized… CONTINUE READING

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Lipoprotein lipase: physiology, biochemistry, and molecular biology.

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