The LPI/GPR55 axis enhances human breast cancer cell migration via HBXIP and p-MLC signaling

@article{Zhou2018TheLA,
  title={The LPI/GPR55 axis enhances human breast cancer cell migration via HBXIP and p-MLC signaling},
  author={Xiaolei Zhou and Xin Guo and Yu-pin Song and Chong-yue Zhu and Wei Zou},
  journal={Acta Pharmacologica Sinica},
  year={2018},
  volume={39},
  pages={459-471}
}
The G protein-coupled receptor 55 (GPR55) is expressed in multiple tissues, and has been implicated in cancer pathogenesis, but little is known about its role in the migratory behavior of cancer cells, particularly breast cancer cells. In this study we first showed that GPR55 expression levels in 38 metastatic lymph nodes of breast cancer patients were profoundly elevated, and were positively associated in human breast cancer cells with their migratory ability. Moreover, the plasma levels of… 
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22 Citations
Background Citations
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Methods Citations
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22 Citations

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Citation Type

The oncogenic lysophosphatidylinositol (LPI)/GPR55 signaling.
The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways
TLDR
The molecular mechanisms underlying the modulation of MDM2/p53 interaction by HBXIP in human breast cancer MCF-7 cells in vitro and in vivo are investigated to shed light on a novel mechanism of p53 down-regulation during the development of breast cancer.
The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis
TLDR
It is found that HBXIP can effectually compete with NRF2 for binding with KEAP1 protein via its highly conserved GLNLG motif, which leads to potent inhibition of the malignancy of breast carcinoma both in vivo and in vitro.
Expression of Lysophosphatidylinositol Signaling-relevant Molecules in Colorectal Cancer
TLDR
DDHD1 expression is associated with depth of tumor invasion in CRC tissues and may be involved in tumor progression, and both roles in the context of CRC are evaluated.
HBXIP is a novel regulator of the unfolded protein response that sustains tamoxifen resistance in ER+ breast cancer
Overexpression of lncRNA H19 leads to reduced proliferation in TSCC cells through miR-675-5p/GPR55
TLDR
The lncRNA H19/miR-675-5p/GPR55 axis might inhibit cell proliferation, invasion and migration in TSCC.
Mast Cell–Tumor Interactions: Molecular Mechanisms of Recruitment, Intratumoral Communication and Potential Therapeutic Targets for Tumor Growth
TLDR
The recent evidence regarding the complex relationship between MCs and tumor cells is reviewed and the novel literature on the molecular mechanisms potentially related to phenotypic changes that MCs undergo into the tumor microenvironment (TME) is discussed.
The oncogenic role of HBXIP.
Gene Expression Data Mining Reveals the Involvement of GPR55 and Its Endogenous Ligands in Immune Response, Cancer, and Differentiation
TLDR
The study revealed that regulation of GPR55 occurs predominantly in the context of immune activation pointing towards the role of the receptor in response to pathogens and in immune cell lineage determination.
The GPR55 antagonist CID16020046 mitigates advanced glycation end products (AGEs)- induced chondrocyte activation.
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