The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy.

Abstract

RATIONALE Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. METHODS In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation. RESULTS Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months. CONCLUSIONS The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.

DOI: 10.1016/j.clim.2014.02.013

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@article{Junge2014TheLC, title={The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy.}, author={Kristin M. Junge and Friederike H{\"{o}rnig and Gunda Herberth and Stefan W. Roeder and Tibor Kohajda and Ulrike Rolle-Kampczyk and Martin von Bergen and Michael Borte and J. Simon and Delia Heroux and Judah A. Denburg and Irina Lehmann}, journal={Clinical immunology}, year={2014}, volume={152 1-2}, pages={68-76} }