The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression.

@article{Hou2008TheLP,
  title={The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression.},
  author={Zhaoyuan Hou and Hongzhuang Peng and Kasirajan Ayyanathan and Kai-ping Yan and Ellen M. Langer and Gregory D. Longmore and F. Rauscher},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 10},
  pages={3198-207}
}
The SNAIL transcription factor contains C-terminal tandem zinc finger motifs and an N-terminal SNAG repression domain. The members of the SNAIL family have recently emerged as major contributors to the processes of development and metastasis via the regulation of epithelial-mesenchymal transition events during embryonic development and tumor progression. However, the mechanisms by which SNAIL represses gene expression are largely undefined. Previously we demonstrated that the AJUBA family of… CONTINUE READING

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The members of the SNAIL family have recently emerged as major contributors to the processes of development and metastasis via the regulation of epithelial - mesenchymal transition events during embryonic development and tumor progression .
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