The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes.

  title={The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes.},
  author={Claudia Rudolf von Rohr and J{\"u}rgen Prestel and Laurence Heidet and Hiltraud Hosser and Wilhelm Kriz and Randy L. Johnson and Corinne Antignac and Ralph Witzgall},
  journal={The Journal of clinical investigation},
  volume={109 8},
Patients with nail-patella syndrome often suffer from a nephropathy, which ultimately results in chronic renal failure. The finding that this disease is caused by mutations in the transcription factor LMX1B, which in the kidney is expressed exclusively in podocytes, offers the opportunity for a better understanding of the renal pathogenesis. In our analysis of the nephropathy in nail-patella syndrome, we have made use of the Lmx1b knockout mouse. Transmission electron micrographs showed that… CONTINUE READING


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