The LIM homeobox gene Lhx9 is essential for mouse gonad formation

@article{Birk2000TheLH,
  title={The LIM homeobox gene Lhx9 is essential for mouse gonad formation},
  author={Ohad S. Birk and Delane E. Casiano and Christopher A Wassif and Tiziana Cogliati and Liping Zhao and Yangu Zhao and Alexander Grinberg and SingPing Huang and Jordan A. Kreidberg and Keith L. Parker and Forbes D Porter and Heiner Westphal},
  journal={Nature},
  year={2000},
  volume={403},
  pages={909-913}
}
During mammalian embryonic development, the ovaries and testes develop from somatic cells of the urogenital ridges as indifferent gonads, harbouring primordial germ cells that have migrated there. After sex determination of the gonads, the testes produce testosterone and anti-Mullerian hormone which mediate male sexual differentiation, and the female developmental pathway ensues in their absence. Here we show that transcripts of the LIM homeobox gene Lhx9 are present in urogenital ridges of… CONTINUE READING
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