The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.

@article{Visvader1997TheLB,
  title={The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.},
  author={Jane E. Visvader and Xiaohong Mao and Yuko Fujiwara and Ki-Baik Hahm and Stuart H Orkin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 25},
  pages={13707-12}
}
The nuclear LIM domain protein LMO2, a T cell oncoprotein, is essential for embryonic erythropoiesis. LIM-only proteins are presumed to act primarily through protein-protein interactions. We, and others, have identified a widely expressed protein, Ldb1, whose C-terminal 76-residues are sufficient to mediate interaction with LMO2. In murine erythroleukemia cells, the endogenous Lbd1 and LMO2 proteins exist in a stable complex, whose binding affinity appears greater than that between LMO2 and the… CONTINUE READING
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