The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus

@article{Lenzen2001TheLR,
  title={The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus},
  author={Sigurd Lenzen and Markus Tiedge and Matthias Elsner and Stephan Lortz and Helmut Weiss and Anne Joerns and G{\"u}nter Kl{\"o}ppel and Dirk Wedekind and Christa Prokop and H. J. Hedrich},
  journal={Diabetologia},
  year={2001},
  volume={44},
  pages={1189-1196}
}
Abstract.Aims/hypothesis: We describe a new Type I (insulin-dependent) diabetes mellitus rat model (LEW.1AR1/Ztm-iddm) which arose through a spontaneous mutation in a congenic Lewis rat strain with a defined MHC haplotype (RT1.Aa B/Du Cu).Methods: The development of diabetes was characterised using biochemical, immunological and morphological methods. Results: Diabetes appeared in the rats with an incidence of 20 % without major sex preference at 58 ± 2 days. The disease was characterised by… CONTINUE READING
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