The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome.

@article{Nowikovsky2004TheLG,
  title={The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome.},
  author={Karin Nowikovsky and Elisabeth Maria Froschauer and G{\'a}bor Zsurka and Jozef {\vS}amaj and Siegfried Reipert and Martin Kolisek and Gerlinde Wiesenberger and Rudolf J. Schweyen},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 29},
  pages={30307-15}
}
The yeast open reading frames YOL027 and YPR125 and their orthologs in various eukaryotes encode proteins with a single predicted trans-membrane domain ranging in molecular mass from 45 to 85 kDa. Hemizygous deletion of their human homolog LETM1 is likely to contribute to the Wolf-Hirschhorn syndrome phenotype. We show here that in yeast and human cells, these genes encode integral proteins of the inner mitochondrial membrane. Deletion of the yeast YOL027 gene (yol027Delta mutation) results in… CONTINUE READING

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