The LCCL module.

  title={The LCCL module.},
  author={M{\'a}ria Trexler and L{\'a}szl{\'o} B{\'a}nyai and L{\'a}szl{\'o} Patthy},
  journal={European journal of biochemistry},
  volume={267 18},
Here we show that Lgl1 protein, cub-1-related proteins, coch-5b2-related proteins, coagulation factor C of horse-shoe crab and a predicted protein of Plasmodium falciparum share a homologous domain. Since this domain-type was first identified in Limulus factor C, Coch-5b2 and Lgl1 we propose the name LCCL for this domain-family. The LCCL module of coch-5b2 is of special biological interest because it has been shown recently that mutations affecting this module cause the deafness disorder DFNA9… CONTINUE READING