The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.

Abstract

The Hippo signaling pathway is a major regulator of organ size. In the liver, Hippo pathway deregulation promotes hyperplasia and hepatocellular carcinoma primarily through hyperactivation of its downstream effector, YAP. The LATS2 tumor suppressor is a core member of the Hippo pathway. A screen for LATS2-interacting proteins in liver-derived cells… (More)
DOI: 10.1101/gad.274167.115

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Cite this paper

@article{Aylon2016TheLT, title={The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.}, author={Yael Aylon and Anat Gershoni and Ron Rotkopf and Inbal Eti Biton and Ziv Porat and A. P. Koh and Xiaochen Sun and Youngmin Lee and M. Isabel Fiel and Yujin Hoshida and Scott L Friedman and Randy L. Johnson and Moshe Oren}, journal={Genes & development}, year={2016}, volume={30 7}, pages={786-97} }