The L84F polymorphism in the O6-Methylguanine-DNA-Methyltransferase (MGMT) gene is associated with increased hypoxanthine phosphoribosyltransferase (HPRT) mutant frequency in lymphocytes of tobacco smokers.

@article{Hill2007TheLP,
  title={The L84F polymorphism in the O6-Methylguanine-DNA-Methyltransferase (MGMT) gene is associated with increased hypoxanthine phosphoribosyltransferase (HPRT) mutant frequency in lymphocytes of tobacco smokers.},
  author={Courtney E Hill and Jeffrey K Wickliffe and Adele T Guerin and Carla J. Kinslow and Kevin J Wolfe and Marinel M Ammenheuser and S. Z. Abdel-Rahman},
  journal={Pharmacogenetics and genomics},
  year={2007},
  volume={17 9},
  pages={743-53}
}
OBJECTIVES O-methylguanine-DNA-methyltransferase (MGMT) is a crucial DNA repair protein that removes DNA adducts formed by alkylating mutagens. Several coding single nucleotide polymorphisms (cSNPs) in the MGMT gene have been reported. Their biological significance, however, is not known. METHODS We used a newly modified cloning HPRT mutant lymphocyte assay to test the hypothesis that inheritance of the L84F and I143V coding single nucleotide polymorphism in the MGMT gene is associated with… CONTINUE READING

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