The L1 adhesion molecule is a cellular ligand for VLA-5

@article{Ruppert1995TheLA,
  title={The L1 adhesion molecule is a cellular ligand for VLA-5},
  author={Margarete Ruppert and Sigrid Aigner and M. Hubbe and H. Yagita and Peter Altevogt},
  journal={The Journal of Cell Biology},
  year={1995},
  volume={131},
  pages={1881 - 1891}
}
The L1 adhesion molecule is a member of the immunoglobulin superfamily shared by neural and immune cells. In the nervous system L1 can mediate cell binding by a homophilic mechanism. To analyze its function on leukocytes we studied whether L1 could interact with integrins. Here we demonstrate that VLA-5, an RGD-specific fibronectin receptor on a wide variety of cell types, can bind to murine L1. Mouse ESb-MP cells expressing VLA-5 and L1 could be induced to aggregate in the presence of specific… CONTINUE READING