The L-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man.

Abstract

OBJECTIVE Effective endogenous fibrinolysis requires rapid release of endothelial tissue plasminogen activator (t-PA). Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. METHODS Blood flow and plasma fibrinolytic and… (More)

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Cite this paper

@article{Newby1998TheLO, title={The L-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man.}, author={David E. Newby and Robert Alan Wright and Pamela Dawson and Christopher A. Ludlam and Nicholas A. Boon and K A A Fox and David J. Webb}, journal={Cardiovascular research}, year={1998}, volume={38 2}, pages={485-92} }