The Kv7.2/Kv7.3 heterotetramer assembles with a random subunit arrangement.

@article{Stewart2012TheKH,
  title={The Kv7.2/Kv7.3 heterotetramer assembles with a random subunit arrangement.},
  author={Andrew P. Stewart and Juan Camilo G{\'o}mez-Posada and Jessica McGeorge and Maral J Rouhani and {\'A}lvaro Villarroel and Ruth D Murrell-Lagnado and J Michael Edwardson},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 15},
  pages={11870-7}
}
Voltage-gated K(+) channels composed of Kv7.2 and Kv7.3 are the predominant contributors to the M-current, which plays a key role in controlling neuronal activity. Various lines of evidence have indicated that Kv7.2 and Kv7.3 form a heteromeric channel. However, the subunit stoichiometry and arrangement within this putative heteromer are so far unknown… CONTINUE READING