The Krüppel-type zinc finger family gene, HKR1, is induced in lung cancer by exposure to platinum drugs.

@article{Oguri1998TheKZ,
  title={The Kr{\"u}ppel-type zinc finger family gene, HKR1, is induced in lung cancer by exposure to platinum drugs.},
  author={Tetsuya Oguri and O Katoh and Toshitada Takahashi and Takeshi Isobe and Ken Kuramoto and Shitau Hirata and Michio Yamakido and Hiromitsu Watanabe},
  journal={Gene},
  year={1998},
  volume={222 1},
  pages={
          61-7
        }
}
To investigate the molecular mechanism associated with the signaling pathway of platinum drug administration, we focused on the C2H2-type zinc finger (ZNF) transcription factor gene family. Here we show cloning of a Krüppel-type ZNF gene, HKR1, which contains Krüppel-associated box (KRAB) domain and ZNF motifs. We found that mRNA expression of the HKR1 gene was induced in lung-cancer cell lines by exposure to cisplatin using Northern blot analysis. Moreover, we also found that HKR1 mRNA… Expand
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TLDR
The cloned cDNA of a novel Krüppel-type zinc finger (ZNF) gene, ZK1, from a cDNA library constructed from the human leukemia cell line, CMK86, using degenerate primers suggests that this gene is one of early response genes by exposure to ionizing radiation and may have some functions on radiation-induced apoptotic cell death on hematopoietic cells. Expand
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