The Kozak sequence polymorphism of platelet glycoprotein Ibalpha and risk of nonfatal myocardial infarction and nonfatal stroke in young women.

@article{Frank2001TheKS,
  title={The Kozak sequence polymorphism of platelet glycoprotein Ibalpha and risk of nonfatal myocardial infarction and nonfatal stroke in young women.},
  author={M B Frank and Alexander P Reiner and Stephen M Schwartz and P N Kumar and Rachel M. Pearce and Patrick G. Arbogast and W. T. Longstreth and Frits R Rosendaal and Bruce M. Psaty and David S Siscovick},
  journal={Blood},
  year={2001},
  volume={97 4},
  pages={
          875-9
        }
}
Several platelet membrane glycoprotein polymorphisms have been identified as potential risk factors for cardiovascular disease. Recently a nucleotide -5T/C dimorphism in the translation initiation site (Kozak sequence) of the platelet glycoprotein Ibalpha (GPIbalpha) gene was associated with increased platelet surface levels of the GPIb-IX-V receptor complex. The role of this GPIbalpha Kozak sequence polymorphism in the occurrence of arterial thrombotic disease is unknown. We performed genotype… CONTINUE READING

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