The Kinases LF4 and CNK2 Control Ciliary Length by Feedback Regulation of Assembly and Disassembly Rates

@article{Hilton2013TheKL,
  title={The Kinases LF4 and CNK2 Control Ciliary Length by Feedback Regulation of Assembly and Disassembly Rates},
  author={Laura K Hilton and K. Gunawardane and Joo Wan Kim and Marianne Schwarz and Lynne M Quarmby},
  journal={Current Biology},
  year={2013},
  volume={23},
  pages={2208-2214}
}
BACKGROUND Many of the diverse functions of cilia depend upon tight control of their length. Steady-state length reflects a balance between rates of ciliary assembly and disassembly, two parameters likely controlled by a length sensor of unknown identity or mechanism. RESULTS A null mutation in Chlamydomonas CNK2, a member of the evolutionarily conserved family of NIMA-related kinases, reveals feedback regulation of assembly and disassembly rates. cnk2-1 mutant cells have a mild long-flagella… CONTINUE READING

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Subcellular size.

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Intraflagellar Transport and Ciliary Dynamics.

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A NIMA-related kinase, CNK4, regulates ciliary stability and length

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