The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast

@article{Cadou2013TheKK,
  title={The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast},
  author={A. Cadou and A. Couturier and C. Le Goff and Linfeng Xie and J. R. Paulson and X. Le Goff},
  journal={Biology of the Cell},
  year={2013},
  volume={105}
}
The Kin1 protein kinase of fission yeast, which regulates cell surface cohesiveness during interphase cell growth, is also present at the cell division site during mitosis; however, its function in cell division has remained elusive. 
Paxillin-Mediated Recruitment of Calcineurin to the Contractile Ring Is Required for the Correct Progression of Cytokinesis in Fission Yeast.
TLDR
It is shown that Pxl1's main function is to recruit calcineurin (CN) phosphatase to the actomyosin ring; and thus the absence of either P xl1 or calcineURin causes similar cytokinesis defects, and the existence of a positive feedback loop between PxL1 and CN is suggested. Expand
Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division
TLDR
These findings uncover a new Ssp1-Kin1 signaling pathway, and define its functional and mechanistic connection with Pom1 signaling for cell polarity and cytokinesis. Expand
Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus.
TLDR
It is shown that kin1 deletion in the human fungal pathogen Aspergillus fumigatus does not affect hyphal growth and septation but results in differential susceptibility to antifungals targeting the cell wall and cell membrane. Expand
Ends and middle: global force balance determines septum location in fission yeast
TLDR
This work tested experimentally whether altered shapes of cell end correlate with a displaced division site, leading to asymmetric cell division and showed that the division site position depends on the radii of curvatures of both ends. Expand
Calcium spikes accompany cleavage furrow ingression and cell separation during fission yeast cytokinesis
TLDR
It is concluded that like the larger animal embryos, fission yeast triggers calcium transients that may play an important role in cytokinesis, and a correlation between the intracellular calcium level and cell division is identified, consistent with the existence of calciumtransients during cytokinesi. Expand
The cleavage furrow ingression and cell separation are both accompanied by calcium spikes during fission yeast cytokinesis
The role of calcium during cell division has long remained ambiguous. The intracellular calcium concentration of many animal embryos increases transiently during cytokinesis, leading to theExpand
Ends and middle: Global force balance and septum location in fission yeast
TLDR
This work tested experimentally whether altered shapes of cell end correlate with a displaced division site, leading to asymmetric cell division, and showed that the division site position depends on the radii of curvatures of both ends. Expand
Calcium spikes accompany the cleavage furrow ingression and cell separation during fission yeast cytokinesis
TLDR
Calcium rises transiently at the division plane during embryonic cell cytokinesis, but the conservation and function of such calcium transients remain unclear, and it is demonstrated that these spikes promote the contractile ring constriction and the daughter cell integrity. Expand
FgKin1 kinase localizes to the septal pore and plays a role in hyphal growth, ascospore germination, pathogenesis, and localization of Tub1 beta-tubulins in Fusarium graminearum.
TLDR
It is shown that KIN1 is important for pathogenesis and growth in two phytopathogenic fungi and that FgKin1 regulates ascospore germination and the localization of Tub1 β-tubulins in Fusarium graminearum. Expand
Calcineurin as a Multifunctional Regulator: Unraveling Novel Functions in Fungal Stress Responses, Hyphal Growth, Drug Resistance, and Pathogenesis.
TLDR
The importance of understanding fungal-specific attributes of calcineurin to decipher fungal pathogenesis and develop novel antifungal therapeutic approaches is reviewed. Expand
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TLDR
In fission yeast, calcineurin has been implicated in cytokinesis because calcineURin‐deleted cells form multiple septa and cell separation is impeded, but this mechanism remains unclear. Expand
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TLDR
This work shows that formation of a sterol-rich membrane domain is independent of the contractile actin ring, septation, mid1p and the septins, and also requires cdc15p, an essential contractile ring protein that associates with lipid rafts. Expand
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TLDR
The earliest step in septum formation and cytokinesis, rearrangement of actin to the center of the cell, is associated with appearance of hypophosphorylated cdc15p and formation of a cDC15p ring, which colocalizes with actin. Expand
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TLDR
The work reveal that nuclear centering becomes essential when Pom1/Tea1/ tea4 function is compromised and that Kin1 expression level is a key regulatory element in this situation and the existence of distinct overlapping control mechanisms to ensure efficient cell division. Expand
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TLDR
The results suggest that correct dosage of kin1p at the cortex is required for spatial organization of the fission yeast cell. Expand
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TLDR
It is found that specific inactivation of Cdc2p in a mitotically arrested cell promotes the asymmetrical recruitment of SIN proteins to the spindle poles and the recruitment of the most downstream SIN components and β-(1,3) glucan synthase to the contractile ring. Expand
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TLDR
Fission yeast polarizes its entire secretory machinery to the cell division site by utilizing molecular cues provided by the actomyosin ring, and an enrichment of the transitional endoplasmic reticulum accompanied by Golgi cisternae biogenesis is observed. Expand
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TLDR
Calcineurin and Mpk1 regulate Swe1 activation at the transcriptional and post-translational levels, respectively, and both are required for the calcium-induced delay in G2 phase, which induce a G2-phase delay in response to hypotonic shock. Expand
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