The Key–Lock Theory and the Induced Fit Theory

@article{Koshland1995TheKT,
  title={The Key–Lock Theory and the Induced Fit Theory},
  author={Daniel E. Koshland},
  journal={Angewandte Chemie},
  year={1995},
  volume={33},
  pages={2375-2378}
}
  • D. Koshland
  • Published 3 January 1995
  • Biology
  • Angewandte Chemie
It is a great pleasure for me to contribute to this symposium honoring the great scientist Emil Fischer. My graduate thesis required me to synthesize [1-14C]glucose, which introduced me to the famous Fischer-Kiliani synthesis of glucose and mannose from arabinose and HCN. [1] I was also particularly intrigued with his classic key-lock (or template) theory of enzyme specificity,[2, 3 ] which like all great theories seemed so obvious once one understood it. This symposium in his honor allows me… 

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