The Ketogenic Diet

@article{Kalra2018TheKD,
  title={The Ketogenic Diet},
  author={Sanjay Kalra and Rajiv Singla and Rahul Rosha and Munish Dhawan and Deepak Khandelwal and Bharti Kalra},
  journal={US endocrinology},
  year={2018},
  volume={14},
  pages={62}
}
The ketogenic diet (KD) is not a new treatment option. In fact, biblical descriptions exist regarding the value of fasting to control seizures. In 1921, Geyelin1 made the earliest scientific observations about the relationship between fasting and seizures, specifically noting that some patients were seizure-free during fast. Later that same year, Wilder speculated that ketonemia has a sedative effect on the brain, mimicking anesthesia. He suggested that, if given enough fat, the body would be… 
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Ketogenic diet, seizure control, and cardiometabolic risk in adult patients with pharmacoresistant epilepsy: a review.

A narrative review provides comprehensive information of the current literature on the effects of KD on lipid profile, glycemic-control biomarkers, and other cardiometabolic risk factors in adult patients with pharmacoresistant epilepsy.

References

SHOWING 1-10 OF 40 REFERENCES

The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children.

The ketogenic diet should be considered as alternative therapy for children with difficult-to-control seizures and is more effective than many of the new anticonvulsant medications and is well tolerated by children and families when it is effective.

The Ketogenic Diet Revisited: Back to the Future

The broad picture regarding the mechanics and the effectiveness of the ketogenic diet has been clear since 1921 and is a time-tested, effective, and safe method for treatment of intractable childhood epilepsy.

Experience with the ketogenic diet in infants.

The ketogenic diet should be considered safe and effective treatment for infants with intractable seizures, particularly with respect to attention/alertness, activity level, and socialization.

Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets

The meaning of physiological ketosis is revisited and whether there are still some preconceived ideas about ketogenic diets, which may be presenting unnecessary barriers to their use as therapeutic tools in the physician's hand are questioned.

Clinical Aspects of the Ketogenic Diet

This critical analysis of the ketogenic diet should provide the impetus for further clinical and basic research into the diet's application and mechanisms of action.

International consensus statement on clinical implementation of the ketogenic diet: Agreement, flexibility, and controversy

A panel comprised of 26 pediatric epileptologists and dietitians with particular expertise in using the ketogenic diet created a consensus statement regarding the clinical management of the KD; the consensus statement has also been endorsed by the Child Neurology Society.

The Ketogenic Diet: One Decade Later

The ketogenic diet, a high fat, adequate protein, low carbohydrate diet, has, during the past decade, had a resurgence of interest for the treatment of difficult-to-control seizures in children. This

Acute Pancreatitis Causing Death in a Child on the Ketogenic Diet

The ketogenic diet has demonstrated good efficacy in children with pharmacologically resistant seizures, but the outcome for this patient raises concern regarding a potential consequence of the ketogenic diets.

CHRONIC KETOSIS AND CEREBRAL METABOLISM

Chronic ketosis effects cerebral metabolism like certain anticonvulsant drugs by slowing brain phosphofructokinase, pyruvate dehydrogenase, and α-ketoglutarate dehydrogenases and it is suggested that each of these metabolic effects contributes to the anticonVulsant action of the ketogenic diet.