The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum

@article{Sarris2009TheKA,
  title={The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum},
  author={Jerome Sarris and David John Kavanagh and Gerard J. Byrne and Kerry Martin Bone and J. Adams and Gary Deed},
  journal={Psychopharmacology},
  year={2009},
  volume={205},
  pages={399-407}
}
RationalePiper methysticum (Kava) has been withdrawn in European, British, and Canadian markets due to concerns over hepatotoxic reactions. The WHO recently recommended research into “aqueous” extracts of Kava.ObjectiveThe objective of this study was to conduct the first documented human clinical trial assessing the anxiolytic and antidepressant efficacy of an aqueous extract of Kava.Design and participantsThe Kava Anxiety Depression Spectrum Study was a 3-week placebo-controlled, double-blind… Expand

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