The Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemia

@article{Larizza2005TheKC,
  title={The Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemia},
  author={L. Larizza and I. Magnani and A. Beghini},
  journal={Leukemia & Lymphoma},
  year={2005},
  volume={46},
  pages={247 - 255}
}
The Kasumi-1 cell line is an intensively investigated model system of Acute Myeloid Leukemia with t(8;21) translocation, that represents 1 of the 2 main subtypes of Core Binding Factor Leukemia (CBFL). Since establishment in 1991 the Kasumi-1 cell line has provided the tool to study the peculiar molecular, morphologic, immunophenotypic findings of AML with t(8;21) and the functional consequences of the AML1-ETO fusion oncogene on myeloid differentiation. Leukemogenesis involves multiple genetic… Expand
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81 Citations
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81 Citations

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CD72 regulates the growth of KIT-mutated leukemia cell line Kasumi-1
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Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation.
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Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and АML1-ETO oncogenes
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The molecular mechanism of the aberrant expression of the B-cell specific PAX5 gene in t(8;21) AML
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Analysis of expression of MSH2 and MSH3 genes in Mixed Lineage Leukemia (MLL)-Acute Lymphoblastic Leukemia (ALL) human cell lines
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UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO
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Aberrant transcriptional regulation of the MLL fusion partner EEN by AML1-ETO and its implication in leukemogenesis.
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A new D816 c-KIT gene mutation in refractory AML1-ETO leukemia.
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Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling
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Amyloid precursor protein cooperates with c-KIT mutation / overexpression to regulate cell apoptosis in AML 1-ETO-positive leukemia via the PI 3 K / AKT signaling pathway
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