The Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemia

  title={The Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemia},
  author={L. Larizza and I. Magnani and A. Beghini},
  journal={Leukemia & Lymphoma},
  pages={247 - 255}
  • L. Larizza, I. Magnani, A. Beghini
  • Published 2005
  • Biology, Medicine
  • Leukemia & Lymphoma
  • The Kasumi-1 cell line is an intensively investigated model system of Acute Myeloid Leukemia with t(8;21) translocation, that represents 1 of the 2 main subtypes of Core Binding Factor Leukemia (CBFL). Since establishment in 1991 the Kasumi-1 cell line has provided the tool to study the peculiar molecular, morphologic, immunophenotypic findings of AML with t(8;21) and the functional consequences of the AML1-ETO fusion oncogene on myeloid differentiation. Leukemogenesis involves multiple genetic… CONTINUE READING
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