The Kallikrein-Related Peptidases hK2 and PSA with Emphasis on Genetic Variation, Secretion, and Sperm Motility

@inproceedings{Svblom2008TheKP,
  title={The Kallikrein-Related Peptidases hK2 and PSA with Emphasis on Genetic Variation, Secretion, and Sperm Motility},
  author={Charlotta S{\"a}vblom},
  year={2008}
}
Prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) are secreted by the prostate into seminal plasma and through leakage into blood. This leakage increases rapidly in prostate disease, and PSA is used worldwide as a marker of prostate cancer. PSA is activated in vitro by hK2, and cleaves the semenogelins in semen, which releases motile sperm, and low levels of PSA have been associated with low sperm motility. The present objective was to evaluate factors that might influence… CONTINUE READING

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