The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells

@article{Sugita1999TheKA,
  title={The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells},
  author={Kanji Sugita and Taijiro Mori and Shouhei Yokota and Ma Kuroki and T O-Koyama and Takeshi Inukai and Kimiko Iijima and Kumiko Goi and Toru Tezuka and Satoru Kojika and Kenji Shiraishi and Makoto Nakamura and Nobuki Miyamoto and N Karakida and Keiko Kagami and Shinpei Nakazawa},
  journal={Leukemia},
  year={1999},
  volume={13},
  pages={779-785}
}
We previously reported a novel monoclonal antibody KOR-SA3544 which predominantly reacted with a surface antigen (sSA3544) expressed on Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL). In the present study, we demonstrate that the antibody specifically recognized nonspecific cross-reacting antigen (NCA)-50/90 (CD66c), one of the carcinoembryonic antigen (CEA)-related glycoproteins encoded by a member of the CEA gene family. In addition, we show that the SA3544 antigen… CONTINUE READING

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