The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms

@article{Nourse2012TheKG,
  title={The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms},
  author={J. Nourse and R. Lea and P. Crooks and G. Wright and Huyen Tran and J. Catalano and T. Brighton and A. Grigg and P. Marlton and M. Gandhi},
  journal={Blood Coagulation & Fibrinolysis},
  year={2012},
  volume={23},
  pages={45–50}
}
  • J. Nourse, R. Lea, +7 authors M. Gandhi
  • Published 2012
  • Medicine
  • Blood Coagulation & Fibrinolysis
  • Adult immune thrombocytopenia (ITP) is a heterogeneous disease and its immunobiology is incompletely understood. Establishing associations between candidate genes and ITP susceptibility may provide insight into pathogenesis. Previous studies have associated overrepresentation of FCGR3a-V158 allele with pediatric ITP. We prospectively accrued DNA from 102 adult patients with persistent/chronic or relapsed primary ITP identified by defined criteria. The distribution of KIR2 genes and… CONTINUE READING
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